Clinical trials of a new antitumor polypeptide: neocarzinostatin (NCS).
نویسندگان
چکیده
Neocarzinostatin, a new polypeptide which had shown antitumor activity in animals, was given to 17 patients with advanced malignant tumors. Five of 17 patients showed objective regression of tumors and disappearance of clinical symptoms. On account of the limited clinical experiences, no assertion can be made as to the range of therapeutic indication or to the comparison of neocarzino statin with other antitumor substances. These preliminary observations, however, justify further extensive therapeutic trials.
منابع مشابه
An antitumor polypeptide antibiotic neocarzinostatin: the mode of apo-protein--chromophore interaction.
The mode of neocarzinostatin-chromophore (NCS-chr)-apo-neocarzinostatin (apo-NCS) interaction in neocarzinostatin (NCS) complex has been described. The NCS-chr release from the NCS complex in the presence of various reagents, which destroy the high-order structure of the protein under various pH conditions, was examined. We found that (i) sodium dodecylsulfate, Nonidet P 40, 8 M urea, and 2-pro...
متن کاملMechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.
The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.
متن کاملEvaluation of succinyl neocarzinostatin in vivo.
The toxicity of the bis-succinyl derivative of the protein antibiotic, neocarzinostatin, was compared with the parent compound, neocarzinostatin (NCS), in rats. The derivative was found to be about two to five fold more active than NCS in vivo. The antitumor activity in rats bearing eleven distinct Yoshida hepatoma ascitic cell lines was tested under four possible combinations with regard to si...
متن کاملA Specific Antagonist of Neocarzinostatin
Streptomyces carzinostaticus produces the antitumor protein, NCS, and at the same time a related protein which antagonizes the antimicrobial effect of NCS. This has been designated pre-neocarzinostatin (pre-NCS). The physicochemical properties of pre-NCS are very close to those of NCS, except for a difference in isoelectric point. Production of pre-NCS in the culture filtrate precedes productio...
متن کاملPeroxy acid as a partial structure of neocarzinostatin (NCS) chromophore.
Sir: Neocarzinostatin (NCS) chromophore was obtained as a separable component from polypeptide antitumor antibiotic NCS by us1,2) and GOLDBERG et al.3,4), independently. This chromophore, which was demonstrated to have biological activities such as growth inhibition of bacterial and tumor cells1), inhibition of DNA synthesis in cultured mammalian cells, strand scission of DNA in vitro and in vi...
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عنوان ژورنال:
- The Tohoku journal of experimental medicine
دوره 98 3 شماره
صفحات -
تاریخ انتشار 1969